Royal Air Force Typhoon FGR4s have operated alongside France's air force in a combined operation on an underground arms cache in Syrian territory used by the Daesh militant organization, according to the UK's MoD.
The site, located using intelligence, was thought to be housing weapons and explosive materials, the announcement noted, and was located in mountains just above the ancient city of Palmyra in central Syria.
"Our fighter planes employed Paveway IV guided bombs to hit a several access tunnels providing entry to the site... preliminary assessments suggest the target was engaged successfully," officials stated.
There was no evidence of any harm to civilians in the attack conducted Saturday night and each participating jet made a safe return, the MoD added.
The Typhoon FGR4s were backed up by a Voyager refuelling tanker.
Daesh - referred to as the so-called Islamic State - enforced militant control over parts of both Syria and Iraq until 2019.
"This operation demonstrates our UK leadership, and determination to operate in unison with allied nations, to stamp out any re-emergence of IS and their harmful and extremist ideologies in the area," UK Defence Secretary the Defence Secretary stated.
UK warplanes have conducted surveillance missions over Syrian airspace to "prevent any efforts to regroup" of Islamic State after its defeat at the battle of Baghuz in 2019, the authorities noted.
"I want to thank all the members of the UK armed forces who took part in this strike for their skill and their bravery," Healey added. "They were among numerous British troops stationed over the festive period. This action, to take out terrorist threats who pose a risk to our safety, shows how our armed forces are prepared to act, throughout the year, protecting the UK within its borders and powerful internationally."
During December, the United States armed forces conducted what it called a "major assault" on IS targets in the country, after an assault claimed the lives of two US troops and a local interpreter in Palmyra.
The UN says Islamic State still maintains between 5,000 and 7,000 militants in both countries.